3139 Acidic FGF (11H11) Rabbit mAb #3139

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"上海博耀生物销售Acidic FGF (11H11) Rabbit mAb #3139，CST原装品质，价格优惠，订购Acidic FGF (11H11) Rabbit mAb #3139，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Acidic FGF (11H11) Rabbit mAb #3139
货号：3139
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3139S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H	Recombinant	17	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Acidic FGF (11H11) Rabbit mAb detects recombinant human aFGF proteins at various concentration. This antibody does not cross-react with human bFGF.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with recombinant human aFGF proteins.
抗体背景：

Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses (1,2). Basic fibroblast growth factor (bFGF or FGF2), initially identified as a mitogen with prominent angiogenic properties, is now recognized as a multifunctional growth factor (3). It is clear that bFGF produces its biological effects in target cells by signaling through cell-surface FGF receptors. bFGF binds to all four FGF receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic downstream target proteins, including FRS-2, PLC and Crk (4,5). The FGF signaling pathway appears to play a significant role not only in normal cell growth regulation but also in tumor development and progression (6).Acidic FGF (aFGF or FGF1) is another extensively investigated protein of the FGF family. aFGF shares 55% DNA sequence homology with bFGF. These two growth factors are ubiquitously expressed and exhibit a wide spectrum of similiar biological activities with quantitative differences likely due to variation in receptor affinity or binding (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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