3144 Phospho-Ezrin (Tyr353) Antibody #3144

"上海博耀生物销售Phospho-Ezrin (Tyr353) Antibody #3144，CST原装品质，价格优惠，订购Phospho-Ezrin (Tyr353) Antibody #3144

"上海博耀生物销售Phospho-Ezrin (Tyr353) Antibody #3144，CST原装品质，价格优惠，订购Phospho-Ezrin (Tyr353) Antibody #3144，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Ezrin (Tyr353) Antibody #3144
货号：3144
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3144S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	80	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Ezrin (Tyr353) Antibody detects endogenous levels of Ezrin only when phosphorylated at tyrosine 353. The antibody does not cross-react with phosphorylated Moesin or Radixin.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr353 of human Ezrin. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The ezrin, radixin, and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling, and microvilli formation (1). ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers (2). Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin) disrupts the amino- and carboxy-terminal association and may play a key role in regulating ERM protein conformation and function (3,4). Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogene-induced transformation (5). Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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