3147 Ezh2 (AC22) Mouse mAb #3147

"上海博耀生物销售Ezh2 (AC22) Mouse mAb #3147，CST原装品质，价格优惠，订购Ezh2 (AC22) Mouse mAb #3147，详情请咨询销售人员

"上海博耀生物销售Ezh2 (AC22) Mouse mAb #3147，CST原装品质，价格优惠，订购Ezh2 (AC22) Mouse mAb #3147，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ezh2 (AC22) Mouse mAb #3147
货号：3147
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
3147S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IF-IC	H M R Mk	Endogenous	98	Mouse IgG1

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ezh2 (AC22) Mouse mAb detects endogenous levels of total Ezh2 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with Ezh2 recombinant protein containing human Ezh2 residues 351-453.
抗体背景：

The polycomb group (PcG) proteins are involved in maintaining the silenced state of several developmentally regulated genes and contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis (1,2). Enhancer of zeste homolog 2 (Ezh2), a member of this large protein family, contains four conserved regions including domain I, domain II, and a cysteine-rich amino acid stretch that precedes the carboxy-terminal SET domain (3). The SET domain has been linked with histone methyltransferase (HMTase) activity. Moreover, mammalian Ezh2 is a member of a histone deacetylase complex that functions in gene silencing, acting at the level of chromatin structure (4). Ezh2 complexes methylate histone H3 at Lys9 and 27 in vitro, which is thought to be involved in targeting transcriptional regulators to specific loci (5). Ezh2 is deregulated in various tumor types, and its role, both as a primary effector and as a mediator of tumorigenesis, has become a subject of increased interest (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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