3135 Phospho-Met (Tyr1003) (13D11) Rabbit mAb #3135

"上海博耀生物销售Phospho-Met (Tyr1003) (13D11) Rabbit mAb #3135，CST原装品质，价格优惠，订购Phospho-Met (Tyr1003) (13D11

"上海博耀生物销售Phospho-Met (Tyr1003) (13D11) Rabbit mAb #3135，CST原装品质，价格优惠，订购Phospho-Met (Tyr1003) (13D11) Rabbit mAb #3135，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Met (Tyr1003) (13D11) Rabbit mAb #3135
货号：3135
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3135P	40 ul (4 western blots)	询价
3135S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R	Endogenous	145	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Met (Tyr1003) (13D11) Rabbit mAb detects endogenous levels of Met only when phosphorylated at Tyr1003. This antibody may cross-react with other activated protein tyrosine kinases.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1003 of human Met.
抗体背景：

Met, a high affinity tyrosine kinase receptor for hepatocyte growth factor (HGF, also known as scatter factor) is a disulfide-linked heterodimer made of 45 kDa α- and 145 kDa β-subunits (1,2). The α-subunit and the amino-terminal region of the β-subunit form the extracellular domain. The remainder of the β-chain spans the plasma membrane and contains a cytoplasmic region with tyrosine kinase activity. Interaction of Met with HGF results in autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl, and PI3 kinase (3). These fundamental events are important for all of the biological functions involving Met kinase activity. The addition of a phosphate at cytoplasmic Tyr1003 is essential for Met protein ubiquitination and degradation (4). Phosphorylation at Tyr1234/1235 in the Met kinase domain is critical for kinase activation. Phosphorylation at Tyr1349 in the Met cytoplasmic domain provides a direct binding site for Gab1 (5). Research studies have shown that altered Met levels and/or tyrosine kinase activities are found in several types of tumors, including renal, colon, and breast. Thus, investigators have concluded that Met is an attractive potential cancer therapeutic and diagnostic target (6,7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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