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大鼠生物活性PTH ELISA试剂盒说明书
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详细介绍
通用名称：大鼠生物活性PTH ELISA试剂盒
英文名称：Rat PTH ELISA
INTENDED USE
This kit is intended for research use only in the determination of rat bioactive intact PTH levels in plasma or cell culture media.
INTRODUCTION
Rat intact parathyroid hormone (PTH) is an 84 amino acid polypeptide produced by the parathyroid gland with its biological activity residing in the N-terminal region of the peptide. PTH plays an important role in maintaining the concentration of ionized calcium within the limits
needed to achieve normal metabolic functions. When serum calcium levels are decreased the parathyroid gland increases secretion of the hormone which results in increased mobilization of calcium from skeletal reserves into the circulation. When levels of serum calcium are increased the secretion of PTH is reduced. The similarities between rat and human physiology relative to calcium metabolism make rat an excellent live-animal model for studying human skeletal disease and in the pre-clinical evaluation of pharmacologic agents that may alter bone remodeling. Quantitation of only full-length biologically active rat intact PTH with this kit can provide a precise and sensitive assessment of changes in bone and mineral
metabolism.
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