DULLARD蛋白抗体实验说明

产品名称：DULLARD蛋白抗体
浓度：1mg/1ml
规格：0.2ml/200μg          
抗体来源：Rabbit  
克隆类型：polyclonal
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse   
产品类型：DULLARD蛋白抗体一抗    
研究领域：神经生物学 信号转导 激酶和磷酸酶 表观遗传学  
蛋白分子量：predicted molecular weight: 28kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human DULLARD
亚型：IgG
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍：In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. Dullard, also known as NET56, is a 244 amino acid single-pass membrane protein that localizes to both the nucleus and the endoplasmic reticulum and contains one FCP1 homology domain. Functioning as a serine/threonine phosphatase, Dullard catalyses the dephosphorylation of target proteins and is thought to be required for proper nuclear membrane morphology. Human Dullard shares 92% sequence identity with its zebrafish counterpart, suggesting a conserved role between species.
Function : DULLARD is a serine/threonine phosphatase which may be required for proper nuclear membrane morphology. It is involved in LPIN1 dephosphorylation and may antagonize BMP signaling.
Subunit : Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.
Subcellular Location : Endoplasmic reticulum membrane; Single-pass membrane protein. Nuclear membrane; Single-pass membrane protein.
Tissue Specificity : Muscle specific with lower expression in other metabolic tissues.
Similarity : Belongs to the dullard family.
Contains 1 FCP1 homology domain.
Database links : UniProtKB/Swiss-Prot: O95476.2