A3317-50 Clozapine N-oxide 50mg

北京优尼康生物科技有限公司主要经营进口、国产生物科研仪器、试剂及耗材，提供技术服务的生物公司之一。现经营的品牌及相关产品如下：

德国Griner培养板、培养皿、离心管、冻存管、培养瓶、接种环、接种针等；

美国Wheaton 匀浆器、组织研磨器、双侧壁细胞培养瓶、悬浮细胞培养瓶、细胞专用搅拌器、安培瓶等玻璃仪器。

美国kimble 蓝盖瓶、匀浆器、离心管，巴氏吸管等玻璃仪器；

加拿大Labplas 的无菌采样袋、均值袋；

美国Nalgene 过滤装置、塑料广口瓶、放水桶、低温冰盒、低温标签、记号笔、离心管、冻存管、便携液氮罐、无菌培养基瓶、手动真空泵等

美国ABI PCR板、PCR管、PCR盖子、八连拍管、膜等

德国Brand 移液器，电动移液器，瓶口分配等

德国艾本德eppendorf 移液器、分配器等

法国Hyphen Biomed 的出血、凝血类试剂 ；

美国BioProducts MD 的PEDF(人眼色素上皮衍生因子)；

德国IBL international 新蝶呤试剂盒、儿茶酚胺试剂盒；

美国TYLER 的筛分仪；

BD公司的基质胶,细胞筛网等;

法国Interscience 均质器、重量稀释器、自动螺旋接种仪、均值袋、均值夹、开袋器、架子等

德国Wiggens 搅拌器、培养箱、振荡器、蒸发器（氮吹仪）菌落计数器本生灯、均质器等

德国Chemvck 防腐隔膜泵、无油泵、真空泵、蠕动泵等

瑞士Keller 小型快速玻璃珠灭菌器、玻璃珠等

美国Millpore 细胞电阻仪、超滤管、膜、针头滤器等

美国 BioSpec研磨珠均质器、手持匀浆机等

自产镍洛合金接种环、接种针、核酸染料等

Clozapine-N-oxide (CNO) is a metabolite of clozapine, which reduces the density of 5-HT2 receptor in rat primary cortical cells. [1] Clozapine-N-oxide (CNO) also activates an evolved M3-muscarinic receptor and then can be used in chemogenetics. [2]

Clozapine is a known atypical antipsychotic medication used in the treatment of schizophrenia. The two major metabolites of clozapine are norclozapine and clozapine-N-oxide (CNO) [3]. Clozapine is also formed from its N-oxide metabolite. It means that a reversible metabolic pathway exists for clozapine and clozapine-N-oxide (CNO) [4]. In rat primary cortical cells and SHS5Y5 neuroblastoma cells, a significant decrease was found for 5-HT2 receptor density with 200 ng/ml clozapine-N-oxide (CNO) [1]. about the method of identification, reversed-phase HPLC has been reported to detect clozapine and its two major metabolites in human plasma[5].

References:
1. P. Heiser, E. Schulte, C. Hausmann, R. Becker, H. Remschmidt, J. C. Krieg and H. Vedder, Prog Neuropsychopharmacol Biol Psychiatry 2004, 28, 297-302.
2. Armbruster BN1, Li X, Pausch MH, et al. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8.
3. S. A. Volpicelli, F. Centorrino, P. R. Puopolo, J. Kando, F. R. Frankenburg, R. J. Baldessarini and J. G. Flood, Clin Chem 1993, 39, 1656-1659.
4. M. W. Jann, Y. W. Lam and W. H. Chang, Arch Int Pharmacodyn Ther 1994, 328, 243-250.
5. A. Avenoso, G. Facciola, G. M. Campo, A. Fazio and E. Spina, J Chromatogr B Biomed Sci Appl 1998, 714, 299-308.