25,26-Dihydroxyvitamin D3

25,26-Dihydroxyvitamin D3是维生素D3代谢物。

MCE (MedChemExpress) 是全球领先的科研化学品和生物活性化合物供应商，总部位于美国新泽西。MCE 的产品范围覆盖各种抑制剂、激动剂和化合物库。

25,26-Dihydroxyvitamin D3是维生素D3代谢物。
25,26-Dihydroxyvitamin D3产品描述：25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity. IC50 value: Target: VD metabolite The biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3.

公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和区总代理，营销网点遍及20多个地区。MCE经过多年努力已成为生物活性小分子领域的供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。
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Purity:96.34%
MWt:416.64
Formula:C27H44O3
SMILES:C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C(CC[C@H](O)C\3)=C)CCCC(O)(C)CO
Pathway:Vitamin D Related;
Mechanisms:VD/VDR;
Research Area:Others




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