3205 Pyruvate Dehydrogenase (C54G1) Rabbit mAb #3205

"上海博耀生物销售Pyruvate Dehydrogenase (C54G1) Rabbit mAb #3205，CST原装品质，价格优惠，订购Pyruvate Dehydrogenase (C54

"上海博耀生物销售Pyruvate Dehydrogenase (C54G1) Rabbit mAb #3205，CST原装品质，价格优惠，订购Pyruvate Dehydrogenase (C54G1) Rabbit mAb #3205，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Pyruvate Dehydrogenase (C54G1) Rabbit mAb #3205
货号：3205
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3205S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P	H M R Mk	Endogenous	43	Rabbit IgG

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Pyruvate Dehydrogenase (C54G1) Rabbit mAb detects endogenous levels of total pyruvate dehydrogenase α1 subunit.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human pyruvate dehydrogenase.
抗体背景：

The pyruvate dehydrogenase complex catalyzes the conversion of pyruvate and CoA into acetyl-CoA and CO₂ in the presence of NAD⁺. Acetyl-CoA then goes into the citric acid cycle where it reacts with oxaloacetate to form citrate. Acetyl-CoA is also used for fatty acid and cholesterol biosynthesis. The reaction of oxidative decarboxylation of pyruvate therefore serves as a critical link between glycolysis and the citric acid cycle and lipid metabolism. In mammalian cells, the pyruvate dehydrogenase complex is located in the mitochondrial matrix (1). This complex is comprised of three enzymes: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Pyruvate dehydrogenase (E1) consists of two subunits: α and β. This enzyme catalyzes the removal of CO₂ from pyruvate. Mutations in the α subunits of pyruvate dehydrogenase (E1) lead to congenital defects that are usually associated with lactic acidosis, neurodegeneration and early death (2).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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