3232 Gab1 Antibody #3232

"上海博耀生物销售Gab1 Antibody #3232，CST原装品质，价格优惠，订购Gab1 Antibody #3232，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售Gab1 Antibody #3232，CST原装品质，价格优惠，订购Gab1 Antibody #3232，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Gab1 Antibody #3232
货号：3232
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3232P	40 ul (4 western blots)	询价
3232S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Mk	Endogenous	110	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Gab1 Antibody detects endogenous levels of total Gab1 protein. This antibody may cross with Gab2 and Gab3.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr472 of human Gab1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold (1-4). Multiple tyrosine phosphorylation sites of Gab1 protein have been identified (5). Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase (6,7). Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ (8). Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2 (6,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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