3197 EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb #3197

"上海博耀生物销售EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb #3197，CST原装品质，价格优惠，订购EGF Receptor (

"上海博耀生物销售EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb #3197，CST原装品质，价格优惠，订购EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb #3197，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb #3197
货号：3197
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3197S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P IF-P IF-IC F	H	Endogenous	175	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-P=Immunofluorescence (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： EGFR (L858R Mutant Specific) (43B2) Rabbit mAb detects endogenous levels of EGFR mutant L858R protein. Careful titration of this antibody may be required to obtain optimal specificity.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to L858R mutant sequence of human EGF receptor.
抗体背景：

The epidermal growth factor (EGF) receptor is a 170 kDa transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Research studies have shown that somatic mutations in the tyrosine kinase domain of EGF receptor (EGFR) are present in a subset of lung adenocarinomas that respond to EGFR inhibitors, such as gefinitib and erlotinib (1-3). Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, that occurs in exon 21 and short in-frame deletions in exon 19 (4,5). The most frequent exon 19 deletion is E746-A750, accounting for 90% of lesions at this site, although some rare variants occur.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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