2854 XLF Antibody #2854

"上海博耀生物销售XLF Antibody #2854，CST原装品质，价格优惠，订购XLF Antibody #2854，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售XLF Antibody #2854，CST原装品质，价格优惠，订购XLF Antibody #2854，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：XLF Antibody #2854
货号：2854
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2854P	40 ul (4 western blots)	询价
2854S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H	Endogenous	39	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： XLF Antibody detects endogenous levels of total XLF protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the carboxy terminus of human XLF. Antibodies are purified by peptide affinity chromatography.
抗体背景：

Double stranded DNA breaks (DSB’s) are the most toxic of DNA lesions. They occur in response to genotoxic stress, and they are also an obligate intermediate in the V(D)J recombination events in the immune system. The mechanism by which cells deal with DSB’s is known as NHEJ (non-homologous end-joining), and involves a core group of proteins that includes Ku, DNA-PK, XRCC4, and XLF (1). XLF, also known as Cernunnos, was originally discovered as a mutated protein from cells of individuals who displayed features of growth retardation, microcephaly, and immunodeficiency (2). These cells were sensitive to ionizing radiation and defective in V(D)J recombination. Exogenous expression of wild type XLF corrected these deficiencies (3), indicating that XLF is a critical component of the NHEJ response. XLF physically interacts with and may stimulate the ligase activity of XRCC4 (3).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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