2865 Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb #2865

"上海博耀生物销售Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb #2865，CST原装品质，价格优惠，订购Phospho-c-Abl (Tyr412) (247

"上海博耀生物销售Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb #2865，CST原装品质，价格优惠，订购Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb #2865，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb #2865
货号：2865
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2865S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H (M)	Endogenous	135 (c-Abl); 210 (Bcr-Abl)	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb detects endogenous Abl proteins only when phosphorylated at tyrosine 412. The antibody does not cross-react with other phosphorylated tyrosine kinases.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr412 of human c-Abl.
抗体背景：

The c-Abl proto-oncogene encodes a nonreceptor protein tyrosine kinase that is ubiquitously expressed and highly conserved in metazoan evolution. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. It is implicated in regulating cell proliferation, differentiation, apoptosis, cell adhesion, and stress responses (1-3). c-Abl kinase activity is increased in vivo by diverse physiological stimuli including integrin activation; PDGF stimulation; and binding to c-Jun, Nck, and RFX1 (2,4). The in vivo mechanism of regulation of c-Abl kinase activity is not completely understood. Tyr245 is located in the linker region between the SH2 and catalytic domains. This positioning is conserved among Abl family members. Phosphorylation at Tyr245 is involved in the activation of c-Abl kinase (5). In addition, phosphorylation at Tyr412, which is located in the kinase activation loop of c-Abl, is required for kinase activity (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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