2820 Ring1A Antibody #2820

"上海博耀生物销售Ring1A Antibody #2820，CST原装品质，价格优惠，订购Ring1A Antibody #2820，详情请咨询销售人员！产品详细参

"上海博耀生物销售Ring1A Antibody #2820，CST原装品质，价格优惠，订购Ring1A Antibody #2820，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ring1A Antibody #2820
货号：2820
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2820S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk	Endogenous	58	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ring1A Antibody detects endogenous levels of total Ring1A protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human Ring1A. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Ring1A plays a role in polycomb group (PcG) protein function. PcG proteins are critically involved in transcriptional repression of Hox genes during development (1,2). PcG proteins form two distinct complexes: EED-EZH2 and the PRC complex, which is composed of at least Bmi1 and Ring1A/Ring1B. The EZH2-containing complex is responsible for the methylation of H3K27, and the PRC complex ubiquitylates H2A. EZH2 methylation is required prior to PRC ubiquitylation, and both are essential for Hox gene repression (3). It has recently been shown that PcG proteins silence a group of developmentally important regulator genes, referred to as bivalent genes (4). This regulation may be responsible for the ability of stem cells to self renew or switch to differentiate into multipotent progenitors. Aberrant epigenetic silencing by PcG proteins is also thought to be important in tumorigenesis (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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