2842 Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb #2842

"上海博耀生物销售Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb #2842，CST原装品质，价格优惠，订购Phospho-HER3/ErbB3 (Ty

"上海博耀生物销售Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb #2842，CST原装品质，价格优惠，订购Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb #2842，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb #2842
货号：2842
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2842S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P	H (M) (R)	Endogenous	185	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb detects endogenous levels of HER3/ErbB3 proteins only when phosphorylated at Tyr1289. The antibody does not cross-react with other phosphorylated receptor tyrosine kinases at significant levels.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1289 of human HER3/ErbB3 protein.
抗体背景：

HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but it lacks tyrosine kinase activity. Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases. Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins, and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase (1,2). There are at least 9 potential tyrosine phosphorylation sites in the carboxy-terminal tail of ErbB3. These sites serve as consensus binding sites for signal transducing proteins, including Src family members, Grb2, and the p85 subunit of PI3 kinase, which mediate ErbB downstream signaling (3). Both Tyr1222 and Tyr1289 of ErbB3 reside within a YXXM motif and participate in signaling to PI3K (4).Investigators have found that ErbB3 is highly expressed in many cancer cells (5) and activation of the ErbB3/PI3K pathway is correlated with malignant phenotypes of adenocarcinomas (6). Research studies have demonstrated that in tumor development, ErbB3 may function as an oncogenic unit together with other ErbB members (e.g. ErbB2 requires ErbB3 to drive breast tumor cell proliferation) (7). Thus, investigators view inhibiting interaction between ErbB3 and ErbB tyrosine kinases as a novel strategy for anti-tumor therapy.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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