2817 MLK3 Antibody #2817

"上海博耀生物销售MLK3 Antibody #2817，CST原装品质，价格优惠，订购MLK3 Antibody #2817，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售MLK3 Antibody #2817，CST原装品质，价格优惠，订购MLK3 Antibody #2817，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MLK3 Antibody #2817
货号：2817
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2817S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Hm Mk	Endogenous	92	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MLK3 Antibody detects endogenous levels of total MLK3 protein. This antibody does not cross-react with MLK1, MLK2 and other mixed lineage kinases.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MLK3. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase that has an amino-terminal SH3 domain followed by the kinase domain and two leucine zippers, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. CRIB triggers the dimerization of MLK3 via its tandem leucine zippers, followed by the intramolecular phosphorylation and subsequent activation of MLK3 (1,2). Autophosphorylation of Thr277 and Ser281 is essential for MLK3 kinase activity (3). Ser281 is also phosphorylated by HPK in an in vitro kinase assay (3). MLK3 functions as a MAPKKK of the SAPK/JNK stress pathway by directly phosphorylating SEK1/MKK4 and MKK7, although it is controversial whether MLK3 is involved in p38 stress pathway activation (1,4). MLK3 also functions as an IκB kinase and mediates the activation of the transcriptional factor NF-κB stimulated by CD3/CD28, suggesting a role for MLK3 in immune and inflammatory responses (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-PALB2乳腺癌易感基因相关蛋白2
ab102939/Anti-CACNA2D3 antibody
ab101640/Anti-ACYP1 antibody
Anti-Fascin1纤维束1抗体
ab102121/Anti-ANKRD42 antibody
ab102841/Anti-DIAPH2 antibody
ab100902/Anti-Cytokeratin 10 antibody
Anti-OPGL/RANKL/ODF骨保护蛋白配体抗体(破骨细胞分化因子)
ab102589/Anti-FOXN2 antibody
Anti-WNK4WNK4抗体
ab103829/Anti-CD1E antibody
ab103193/Anti-ABCF3 antibody
Anti-Dynamin 2酶动力蛋白2抗体
Anti-Cyclin D1/FSTL3周期素D1抗体
Anti-PCDHGA4原钙粘蛋白γA4抗体
ab101859/Anti-CPLX3 antibody"
本页产品地址：http://www.geilan.com/sell/show-3244610.html