2781 Phospho-FADD (Ser194) Antibody (Human Specific) #2781

"上海博耀生物销售Phospho-FADD (Ser194) Antibody (Human Specific) #2781，CST原装品质，价格优惠，订购Phospho-FADD (Ser194)

"上海博耀生物销售Phospho-FADD (Ser194) Antibody (Human Specific) #2781，CST原装品质，价格优惠，订购Phospho-FADD (Ser194) Antibody (Human Specific) #2781，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-FADD (Ser194) Antibody (Human Specific) #2781
货号：2781
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2781S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	28	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-FADD (Ser194) Antibody (Human Specific) detects endogenous levels of human FADD protein only when phosphorylated at serine 194.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser194 of human FADD. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Fas-associated death domain (FADD or Mort 1) functions as an important adaptor in coupling death signaling from membrane receptors, such as the Fas ligand and TNF family (DR3, DR4 and DR5), to caspase-8 (1,2). FADD has a carboxy-terminal death domain, which interacts with the cytoplasmic tail of the membrane receptor, and an amino-terminal death effector domain, which interacts with caspase-8. Clustering of the receptors upon stimulation brings about FADD and caspase-8 oligomerization, activating the caspase signaling pathway. Human FADD is phosphorylated mainly at Ser194, while mouse FADD is phosphorylated at Ser191. In both cases, the phosphorylation is cell cycle-dependent (3) and may be related to its regulatory role in embryonic development and cell cycle progression (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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