2796 Lyn (C13F9) Rabbit mAb #2796

"上海博耀生物销售Lyn (C13F9) Rabbit mAb #2796，CST原装品质，价格优惠，订购Lyn (C13F9) Rabbit mAb #2796，详情请咨询销售人

"上海博耀生物销售Lyn (C13F9) Rabbit mAb #2796，CST原装品质，价格优惠，订购Lyn (C13F9) Rabbit mAb #2796，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Lyn (C13F9) Rabbit mAb #2796
货号：2796
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2796P	40 ul (4 western blots)	询价
2796S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P	H M R Mk	Endogenous	56	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Lyn (C13F9) Rabbit mAb detects endogenous levels of total Lyn protein. This antibody does not cross-react with any other Src-family members.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human Lyn.
抗体背景：

Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells (1). Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivalent to Tyr416 of Src), located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 (equivalent to Tyr527 of Src) inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor (BCR) and CD40 (2-4). Studies using knockout mice have shown that the net effect of Lyn deficiency is to render B cells hypersensitive to BCR stimulation (5-7), suggesting that the most critical role for Lyn in vivo is in the down-regulation of B cell responses. Lyn is also involved in controlling the migration and development of specific B cell populations (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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