2716 MO25α/CAB39 (C49D8) Rabbit mAb #2716

"上海博耀生物销售MO25α/CAB39 (C49D8) Rabbit mAb #2716，CST原装品质，价格优惠，订购MO25α/CAB39 (C49D8) Rabbit mAb #2716

"上海博耀生物销售MO25α/CAB39 (C49D8) Rabbit mAb #2716，CST原装品质，价格优惠，订购MO25α/CAB39 (C49D8) Rabbit mAb #2716，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MO25α/CAB39 (C49D8) Rabbit mAb #2716
货号：2716
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2716S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	39	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MO25α/CAB39 (C49D8) Rabbit mAb detects endogenous levels of total MO25α/CAB39 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human MO25α/CAB39.
抗体背景：

AMPK (AMP-activated protein kinase) is a key cellular component that regulates energy homeostasis (1,2). When the AMP/ATP ratio is increased due to energy depletion, AMPK is phosphorylated at its α1 and α2 catalytic subunits and activated (3). Studies showed that the tumor suppressor LKB1 phosphorylates and activates AMPK in mammals (4,5). MO25α (mouse protein 25α), also called CAB39 (calcium binding protein 39), is a component of the LKB1 complex in vivo (5,6). MO25α/CAB39 does not directly interact with LKB1; instead, it is physically associated with STRADα (6). Together MO25α/CAB39 and STRADα help anchor LKB1 in the cytoplasm (6). MO25α/CAB39 stablizes the LKB1-STRADα complex and further increases the catalytic activity of LKB1 (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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