2691 PRAS40 (D23C7) Rabbit mAb #2691

"上海博耀生物销售PRAS40 (D23C7) Rabbit mAb #2691，CST原装品质，价格优惠，订购PRAS40 (D23C7) Rabbit mAb #2691，详情请咨询

"上海博耀生物销售PRAS40 (D23C7) Rabbit mAb #2691，CST原装品质，价格优惠，订购PRAS40 (D23C7) Rabbit mAb #2691，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PRAS40 (D23C7) Rabbit mAb #2691
货号：2691
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2691P	40 ul (4 western blots)	询价
2691S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P	H M R Mk	Endogenous	40	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PRAS40 (D23C7) XP^® Rabbit mAb detects endogenous levels of total PRAS40 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human PRAS40.
抗体背景：

Many growth factors and hormones induce the phosphoinositide 3-kinase signaling pathway, which results in the activation of downstream effector proteins such as the serine/threonine kinase Akt (1,2). One known Akt substrate is a 40 kDa, proline-rich protein (PRAS40) that binds to 14-3-3 proteins (2). PRAS40 also binds mTOR to transduce Akt signals to the mTOR complex. Inhibition of mTOR signaling stimulates PRAS40 binding to mTOR, which in turn inhibits mTOR activity (3). PRAS40 interacts with raptor in mTOR complex 1 (mTORC1) in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1 (4). mTORC1 in turn phosphorylates PRAS40 at Ser183 (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-PEG10肝癌高表达基因抗体
Anti-LAMR1层粘连蛋白受体1抗体（N端）
ab102047/Anti-FAM109A antibody
Anti-CA125/MUC16卵巢癌抗原抗体
ab101173/Anti-beta Actin antibody
ab103422/Anti-Calcitonin receptor antibody
ab10354/Anti-ASIC3 antibody
Anti-ADNP/NAP活性依赖的神经保护肽抗体
ab101364/Anti-DCUN1D2 antibody
Anti-MCSF/M-CSF巨噬细胞克隆刺激因子抗体
Anti-ERK2/MAPK1丝裂原活化蛋白激酶1抗体
Anti-HSP90 alpha热休克蛋白90α/HSP90 α抗体
ab102645/Anti-GRASP65 antibody
ab101429/Anti-C3IP1 antibody
Anti-HGF肝细胞生长因子抗体
ab101858/Anti-CPLX3 + CPLX4 antibody"
本页产品地址：http://www.geilan.com/sell/show-3243755.html