2678 IKKβ (L570) Antibody #2678

"上海博耀生物销售IKKβ (L570) Antibody #2678，CST原装品质，价格优惠，订购IKKβ (L570) Antibody #2678，详情请咨询销售人员

"上海博耀生物销售IKKβ (L570) Antibody #2678，CST原装品质，价格优惠，订购IKKβ (L570) Antibody #2678，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：IKKβ (L570) Antibody #2678
货号：2678
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2678P	40 ul (4 western blots)	询价
2678S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Hm Mk B GP	Endogenous	87	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key  B=Bovine  GP=Guinea Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： IKKβ (L570) Antibody detects endogenous levels of total IKKβ protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu570 of IKKβ protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation (10-13).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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