2541 Phospho-Paxillin (Tyr118) Antibody #2541

"上海博耀生物销售Phospho-Paxillin (Tyr118) Antibody #2541，CST原装品质，价格优惠，订购Phospho-Paxillin (Tyr118) Antibody

"上海博耀生物销售Phospho-Paxillin (Tyr118) Antibody #2541，CST原装品质，价格优惠，订购Phospho-Paxillin (Tyr118) Antibody #2541，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Paxillin (Tyr118) Antibody #2541
货号：2541
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2541S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IF-IC	H M R Mk Pg	Endogenous	68	Rabbit

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Paxillin (Tyr118) Antibody detects endogenous levels of paxillin only when phosphorylated at tyrosine 118. The antibody does not cross-react with other tyrosine phosphorylated proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr118 of human paxillin. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix (1). Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization (2). Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 (3,4). Phospho-FAK (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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