2537 Phospho-AMPKα1 (Ser485) (45F5) Rabbit mAb #2537

"上海博耀生物销售Phospho-AMPKα1 (Ser485) (45F5) Rabbit mAb #2537，CST原装品质，价格优惠，订购Phospho-AMPKα1 (Ser485) (

"上海博耀生物销售Phospho-AMPKα1 (Ser485) (45F5) Rabbit mAb #2537，CST原装品质，价格优惠，订购Phospho-AMPKα1 (Ser485) (45F5) Rabbit mAb #2537，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-AMPKα1 (Ser485) (45F5) Rabbit mAb #2537
货号：2537
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2537S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk	Endogenous	62 kDa	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-AMPKα1 (Ser485) (45F5) Rabbit mAb detects endogenous levels of AMPKα1 only when phosphorylated at Ser485. The antibody does not cross-react with phosphorylated AMPKα2 or other related proteins.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser485 of human AMPKα1.
抗体背景：

AMP-activated protein kinase (AMPK) is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy homeostasis (1). AMPK is a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits, each of which is encoded by two or three distinct genes (α1, 2; β1, 2; γ1, 2, 3) (2). The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia, and ischemia (1). The tumor suppressor LKB1, in association with accessory proteins STRAD and MO25, phosphorylates AMPKα at Thr172 in the activation loop, and this phosphorylation is required for AMPK activation (3-5). AMPKα is also phosphorylated at Thr258 and Ser485 (for α1; Ser491 for α2). The upstream kinase and the biological significance of these phosphorylation events have yet to be elucidated (6). The β1 subunit is post-translationally modified by myristoylation and multi-site phosphorylation including Ser24/25, Ser96, Ser101, Ser108, and Ser182 (6,7). Phosphorylation at Ser108 of the β1 subunit seems to be required for the activation of AMPK enzyme, while phosphorylation at Ser24/25 and Ser182 affects AMPK localization (7). Several mutations in AMPKγ subunits have been identified, most of which are located in the putative AMP/ATP binding sites (CBS or Bateman domains). Mutations at these sites lead to reduction of AMPK activity and cause glycogen accumulation in heart or skeletal muscle (1,2). Accumulating evidence indicates that AMPK not only regulates the metabolism of fatty acids and glycogen, but also modulates protein synthesis and cell growth through EF2 and TSC2/mTOR pathways, as well as blood flow via eNOS/nNOS (1).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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