2460 AMPA Receptor (GluR 2/3/4) Antibody #2460

"上海博耀生物销售AMPA Receptor (GluR 2/3/4) Antibody #2460，CST原装品质，价格优惠，订购AMPA Receptor (GluR 2/3/4) Antibo

"上海博耀生物销售AMPA Receptor (GluR 2/3/4) Antibody #2460，CST原装品质，价格优惠，订购AMPA Receptor (GluR 2/3/4) Antibody #2460，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：AMPA Receptor (GluR 2/3/4) Antibody #2460
货号：2460
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2460S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R	Endogenous	100	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： AMPA Receptor (GluR 2/3/4) Antibody detects endogenous levels of total GluR 2/3/4 protein. It may also detect GluR1.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser720 of human GluR2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

AMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite-, and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4), which assemble as homo- or hetero-tetramers to mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). AMPARs that lack GluR 2 are permeable to calcium, in contrast to GluR 2-containing AMPARs (2). Post-transcriptional modifications (alternative splicing, nuclear RNA editing) and post-translational modifications (glycosylation, phosphorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer’s, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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