2463 VEGF-B Antibody #2463

"上海博耀生物销售VEGF-B Antibody #2463，CST原装品质，价格优惠，订购VEGF-B Antibody #2463，详情请咨询销售人员！产品详细参

"上海博耀生物销售VEGF-B Antibody #2463，CST原装品质，价格优惠，订购VEGF-B Antibody #2463，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：VEGF-B Antibody #2463
货号：2463
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2463S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Recombinant	20	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： VEGF-B Antibody detects recombinant human VEGF-B protein at various concentrations. This antibody does not cross-react with other VEGF family members.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly155 of human VEGF-B. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. VEGF and its close relatives VEGF-B, -C and -D form a subfamily within PDGF family of growth factors, which belongs to the cysteine knot class of cytokines. Five VEGF isoforms of 121, 145, 165, 189 and 206 amino acids (VEGF121–206) are generated as a result of alternative splicing from a single VEGF gene (1).The various VEGF forms bind to three tyrosine-kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3 which are expressed almost exclusively in endothelial cells. VEGFR-2 is the main angiogenic signal transducer for VEGF, while VEGFR-3 is specific for VEGF-C and -D and is necessary and sufficient for lymphangiogenic signaling. However, upon proteolytic processing VEGF-C and -D gain the ability to also bind and activate VEGFR-2 (2). Guided by the binding properties of the ligands, the VEGFRs are able to form both homodimers and heterodimers. Receptor dimerization is accompanied by activation of receptor kinase activity leading to receptor autophosphorylation. Phosphorylated receptors recruit interacting proteins and induce downstream signaling (3). Recently, tumor therapies based on neutralizing anti-VEGF antibodies and small molecule tyrosine kinase inhibitors targeting VEGFRs have been developed. These new strategies for tumor treatment show the clinical relevance of inhibiting VEGF signal transduction pathways that are exaggerated in pathological angiogenesis (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103547/Anti-CYP2C8 antibody
ab103422/Anti-Calcitonin receptor antibody
Anti-CD79A/IGBP-1免疫球蛋白结合蛋白-1抗体
ab10397/Anti-CCR5 antibody
Anti-IGF1R/CD221胰岛素样生长因子1受体抗体
Anti-TRA16睾丸激素孤儿受体相关蛋白抗体
ab10072/Anti-alpha 1 Fetoprotein antibody
ab101398/Anti-FLJ39155 antibody
Anti-PKB/AKT-1蛋白激酶B
Anti-Collagen VⅤ型胶原抗体
Anti-DCP异常凝血酶原/脱-γ-羧基凝血酶原抗体
Anti-FAM98AFAM98A蛋白抗体
Anti-MICA/MHC IMHC I类链相关蛋白A/组织相容性复合物1抗体
ab101832/Anti-BPIL2 antibody
ab103347/Anti-FARS2 antibody
ab103980/Anti-Gasdermin like antibody"
本页产品地址：http://www.geilan.com/sell/show-3242631.html