2434 Phospho-Shc (Tyr239/240) Antibody #2434

"上海博耀生物销售Phospho-Shc (Tyr239/240) Antibody #2434，CST原装品质，价格优惠，订购Phospho-Shc (Tyr239/240) Antibody #

"上海博耀生物销售Phospho-Shc (Tyr239/240) Antibody #2434，CST原装品质，价格优惠，订购Phospho-Shc (Tyr239/240) Antibody #2434，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Shc (Tyr239/240) Antibody #2434
货号：2434
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2434P	40 ul (4 western blots)	询价
2434S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R	Endogenous	50, 55, 70	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Shc (Tyr239/240) Antibody detects Shc only when phosphorylated at tyrosine 239/240. The antibody may cross-react with activated EGF receptor protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr239/240 of human Shc. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Shc possesses SH2 and PTB domains and serves as a scaffold protein in signaling for a variety of receptor tyrosine kinases. Shc exists in p46, p52 and p66 isoforms, which are produced by using alternative translation initiation sites or a differentially spliced message (1-3). In response to extracellular signals, the SH2 and PTB domains of Shc interact with the activated receptors, leading to phosphorylation of Shc on three different tyrosine residues: Tyr239, Tyr240 and Tyr317 (4-6). GRB2/Sos binds to Shc phosphorylated at these sites, activating the Ras/Raf/MAPK pathway (4). Both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab102694/Anti-AP180 antibody
Anti-ArteminArtemin抗体
Anti-IL-13白介素13抗体
ab103493/Anti-GAS2L3 antibody
Anti-FABP7/BLBP/FABP(brain) CT脑型脂肪酸结合蛋白抗体(C端)
ab101036/Anti-GABA A Receptor gamma 2 antibody
ab103119/Anti-Carbonic Anhydrase III antibody
Anti-PCNA增殖细胞核抗原抗体
ab103176/Anti-C3orf23 antibody
ab103349/Anti-ACOX3 antibody
Anti-Thioredoxin硫氧还蛋白抗体
Anti-PAX3配对盒基因3抗体
ab101357/Anti-CCDC90B antibody
ab103980/Anti-Gasdermin like antibody
ab103282/Anti-Alpha B Crystallin (phospho S59) antibody
Anti-NRP1/CD304神经纤毛蛋白1抗体"
本页产品地址：http://www.geilan.com/sell/show-3242572.html