2440 Mig6 Antibody #2440

"上海博耀生物销售Mig6 Antibody #2440，CST原装品质，价格优惠，订购Mig6 Antibody #2440，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售Mig6 Antibody #2440，CST原装品质，价格优惠，订购Mig6 Antibody #2440，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Mig6 Antibody #2440
货号：2440
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2440S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	51	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Mig6 Antibody detects endogenous levels of total Mig6 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val195 of human Mig6. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Mig6 was identified as a gene which is induced when quiescent fibroblasts are treated by mitogens (1). During cell cycle progression, Mig6 expression levels are also regulated (1). Mig6 mRNA levels were found to increase upon stimulation by chronic stresses including diabetic nephropathy (2). Overexpression of this gene leads to the activation of stress-activated protein kinases (SAPKs)/c-Jun amino-terminal kinases (JNKs) (2). Furthermore, Mig6 was found to interact with epidermal growth factor receptor (EGFR) when stimulated by epidermal growth factor (EGF) (3). Deletion of the Mig6 gene in mice results in hyperactivation of EGFR and signaling through the mitogen-activated protein kinase (MAPK) pathway, causing overproliferation and abnormal differentiation of epidermal keratinocytes in these animals. Inhibition of endogenous EGFR signaling by Iressa abolished skin defects observed in Mig6^(-/-) mice, indicating that Mig6 is a specfic negative regulator of EGFR signaling (4). Furthermore, expression of Mig6 was significantly lower in skin, breast, pancreatic and ovarian cancers, suggesting a role of Mig6 as a tumor suppressor (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab101700/Anti-BDKRB1 antibody
ab10370/Anti-Eotaxin 2 antibody
Anti-Lpin1 proteinLpin1 抗体
ab101916/Anti-GSTA3 antibody
ab10272/Anti-Delta Opioid Receptor antibody
ab10066/Anti-Fibrinogen antibody
Anti-SM-MHC心肌肌球蛋白抗体（α-myosin）
Anti-ERAB/HSD17B10内质网Aβ相关结合蛋白抗体
ab10424/Anti-FGF9 antibody
ab102816/Anti-GSTA3 antibody
ab103540/Anti-CRLF3 antibody
ab10369/Anti-Eotaxin antibody
Anti-FGF1/AFGF酸性成纤维细胞生长因子抗体
Anti-LAT/LAT1T细胞活化连接蛋白抗体
Anti-Plakophilin 2桥粒斑菲素蛋白2抗体
ab102822/Anti-AGR3 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242579.html