2198 RPA70 (4D9) Rat mAb #2198

"上海博耀生物销售RPA70 (4D9) Rat mAb #2198，CST原装品质，价格优惠，订购RPA70 (4D9) Rat mAb #2198，详情请咨询销售人员！产

"上海博耀生物销售RPA70 (4D9) Rat mAb #2198，CST原装品质，价格优惠，订购RPA70 (4D9) Rat mAb #2198，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：RPA70 (4D9) Rat mAb #2198
货号：2198
品牌：CST(cell signaling)
抗体来源：Rat
克隆类型： Monoclonal
规格：

No.	Size	Price
2198S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IF-IC	H Mk	Endogenous	70	Rat IgG1

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： RPA70 (4D9) Rat mAb detects endogenous levels of total RPA70 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a recombinant MBP-fusion protein corresponding to the carboxy-terminal sequence of human RPA70.
抗体背景：

RPA70 (HSSB, REPA1, RF-A, RP-A, p70) is a component of a heterotrimeric complex, composed of 70, 32/30 and 14 kDa subunits, collectively known as RPA. RPA is a single stranded DNA binding protein, whose DNA binding activity is believed to reside entirely in the 70 kDa subunit. The complex is required for almost all aspects of cellular DNA metabolism such as DNA replication (1-3), recombination, cell cycle and DNA damage checkpoints, and all major types of DNA repair including nucleotide excision, base excision, mismatch and double-strand break repairs (4-7). In response to genotoxic stress in eukaryotic cells, RPA has been shown to associate with the Rad9/Rad1/Hus1 (9-1-1) checkpoint complex (8). RPA is hyperphosphorylated upon DNA damage or replication stress by checkpoint kinases including ataxia telangiectasia mutated (ATM), ATM and Rad3-related (ATR), and DNA-dependent protein kinase (DNA-PK) (9-11). Hyperphosphorylation may alter RPA-DNA and RPA-protein interactions. In addition to the checkpoint partners, RPA interacts with a wide variety of protein partners, including proteins required for normal replication such as RCF, PCNA and Pol α, and also proteins involved in SV40 replication, such as DNA polymerase I and SV40 large T antigen (10,12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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