2180 Ku80 (C48E7) Rabbit mAb #2180

"上海博耀生物销售Ku80 (C48E7) Rabbit mAb #2180，CST原装品质，价格优惠，订购Ku80 (C48E7) Rabbit mAb #2180，详情请咨询销售

"上海博耀生物销售Ku80 (C48E7) Rabbit mAb #2180，CST原装品质，价格优惠，订购Ku80 (C48E7) Rabbit mAb #2180，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ku80 (C48E7) Rabbit mAb #2180
货号：2180
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2180P	40 ul (4 western blots)	询价
2180S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P IHC-F IF-IC	H Mk	Endogenous	86	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IHC-F=Immunohistochemistry (Frozen)  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ku80 (C48E7) Rabbit mAb detects endogenous levels of total Ku80 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human Ku80.
抗体背景：

Ku is a heterodimeric protein composed of two subunits (Ku70 and Ku80) originally identified by researchers as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis, and systemic lupus erythematosus (1). Ku is an abundant, ubiquitously expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks (2-5). The Ku70/Ku80 heterodimer has ATP-dependent DNA helicase activity and functions as the DNA-binding regulatory component of DNA-dependent protein kinase (DNA-PK) (6-8). The assembly of the DNA-PK complex at DNA ends is required for nonhomologous end-joining (NHEJ), one mechanism involved in double-stranded DNA break repair and V(D)J recombination (8). DNA-PK has been shown to phosphorylate many proteins, including p53, serum response factor, c-Jun, c-Fos, c-Myc, Oct-1, Sp-1, and RNA polymerase II (1,8). The combined activities of Ku70/Ku80 and DNA-PK implicate Ku in many cellular functions, including cell cycle regulation, DNA replication and repair, telomere maintenance, recombination, and transcriptional activation.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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