2080 CHIP (C3B6) Rabbit mAb #2080

"上海博耀生物销售CHIP (C3B6) Rabbit mAb #2080，CST原装品质，价格优惠，订购CHIP (C3B6) Rabbit mAb #2080，详情请咨询销售人

"上海博耀生物销售CHIP (C3B6) Rabbit mAb #2080，CST原装品质，价格优惠，订购CHIP (C3B6) Rabbit mAb #2080，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CHIP (C3B6) Rabbit mAb #2080
货号：2080
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2080S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	32	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： CHIP (C3B6) Rabbit mAb detects endogenous levels of total CHIP protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues around Leu36 of human CHIP.
抗体背景：

The carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome system (1). Cytoplasmic CHIP protein contains three 34-amino acid TPR (tetratricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domain. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domain (2,3). The binding of CHIP to Hsp70 can stall the folding of Hsp70 client proteins and concomitantly facilitate the U-box dependent ubiquitination of Hsp70-bound substrates (4-6). CHIP appears to play a central role in cell stress protection (7) and is responsible for the degradation of disease-related proteins that include cystic fibrosis transmembrane conductance regulator (4), p53 (8), huntingtin and Ataxin-3 (9), Tau protein (10), and α-synuclein (11).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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