2072 Histone Deacetylase 4 (HDAC4) Antibody #2072

"上海博耀生物销售Histone Deacetylase 4 (HDAC4) Antibody #2072，CST原装品质，价格优惠，订购Histone Deacetylase 4 (HDAC4)

"上海博耀生物销售Histone Deacetylase 4 (HDAC4) Antibody #2072，CST原装品质，价格优惠，订购Histone Deacetylase 4 (HDAC4) Antibody #2072，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Histone Deacetylase 4 (HDAC4) Antibody #2072
货号：2072
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2072S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk	Endogenous	140	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Histone Deacetylase 4 (HDAC4) Antibody detects endogenous levels of total HDAC4 protein. This antibody detects only HDAC4 protein; it does not cross-react with other HDAC proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 10 of human HDAC4. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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