Background: Fat 1 is a protein that in humans is encoded by the FAT1 gene. This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
Specificity: Rabbit anti- FAT tumor suppressor homolog 1(FAT1) polyclonal Antibody.
Reacts with: Human
Application: ELISA=1:500-1000
IHC-P=1:100-500
IHC-F=1:100-500
IF=1:50-200
WB=1:20-200
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The Lyophilized or Liquid antibody is stable at room temperature for at least one month and for greater than a year when kept at -20 °C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
