S期激酶活化蛋白DBF4B抗体简介说明

英文名称    DBF4B    
中文名称    S期激酶活化蛋白DBF4B抗体    
别    名    Activator of S phase kinase like protein 1; ASK like protein 1; ASKL1; chifb; Chiffon homolog B; DBF 4B; DBF4 homolog B (S. cerevisiae); DBF4 homolog B; Dbf4 related factor 1; DRF1; Protein DBF4 homolog B; ZDBF1B; Zinc finger DBF type containing 1B; DBF4B_HUMAN.    
规    格    0.2ml      
研究领域    肿瘤  细胞生物  免疫学  信号转导  细胞周期蛋白  激酶和磷酸酶  表观遗传学      
抗体来源    Rabbit    
克隆类型    Polyclonal    
交叉反应    Human,     
产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 S期激酶活化蛋白DBF4B抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    18kDa    
细胞定位    细胞核     
性    状    Lyophilized or Liquid    
浓    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DBF4B/ASKL1    
亚    型    IgG    
纯化方法    affinity purified by Protein A    
储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

S期激酶活化蛋白DBF4B抗体产品介绍    background:
DBF4B is a regulatory subunit for CDC7, a serine-threonine kinase which links cell cycle regulation to genome duplication. The complex CDC7-DBF4B selectively phosphorylates the MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. DBF4B localizes to the nucleus and its expression is cell cycle-regulated.

Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.

Subunit:
Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4/DBF4A or DBF4B. Such complexes are stable upon replication stress.

Subcellular Location:
Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.

Tissue Specificity:
Widely expressed. Highly expressed in testis.

Post-translational modifications:
Phosphorylated.