神经细胞特异性转录因子DAT1抗体简介

英文名称    DAT1/LIM domain only 3    
中文名称    神经细胞特异性转录因子DAT1抗体    
别    名    DAT 1; DAT1; LIM domain only 3 (rhombotin like 2); LIM domain only protein 3; LMO 3; LMO3; Neuronal specific transcription factor DAT1; RBTN 3; RBTN3; RBTNL 2; RBTNL2; RHOM 3; RHOM3; Rhombotin 3; Rhombotin like 2; Rhombotin3; LMO3_HUMAN.    
规格    0.2ml      
研究领域    肿瘤  免疫学  染色质和核信号  神经生物学      
抗体来源    Rabbit    
克隆类型    Polyclonal    
交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     
产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 神经细胞特异性转录因子DAT1抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    16kDa    
细胞定位    细胞膜     
性    状    Lyophilized or Liquid    
浓    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DAT1/LIM domain only 3    
亚    型    IgG    
纯化方法    affinity purified by Protein A    
储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

神经细胞特异性转录因子DAT1抗体产品介绍    background:
LIM domain only 3 (LMO3) belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. It is transcribed mainly in the brain. It interacts with the neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.

Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Subcellular Location:
Membrane.

DISEASE:
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.

Similarity:
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.