3341 Phospho-ALK (Tyr1604) Antibody #3341

"上海博耀生物销售Phospho-ALK (Tyr1604) Antibody #3341，CST原装品质，价格优惠，订购Phospho-ALK (Tyr1604) Antibody #3341，

"上海博耀生物销售Phospho-ALK (Tyr1604) Antibody #3341，CST原装品质，价格优惠，订购Phospho-ALK (Tyr1604) Antibody #3341，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-ALK (Tyr1604) Antibody #3341
货号：3341
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3341S	100 ul (10 western blots)	询价
3341L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H	Endogenous	80 (NPM-ALK) 220 (ALK)	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-ALK (Tyr1604) Antibody detects ALK only when phosphorylated at Tyr1604 (equivalent to Tyr664 of NPM-ALK). This antibody may cross-react with other activated protein tyrosine kinases including EGFR.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1604 of human ALK. Antibodies are purified by protein A and peptide affinity chromatography
抗体背景：

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development (1-3). In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, and PI3 kinase (1). ALK was originally discovered as a nucleophosmin (NPM)-ALK fusion protein produced by a translocation (4). Investigators have found that the NPM-ALK fusion protein is a constitutively active, oncogenic tyrosine kinase associated with anaplastic lymphoma (4). Research literature suggests that activation of PLCγ by NPM-ALK may be a crucial step for its mitogenic activity and involved in the pathogenesis of anaplastic lymphomas (5).A distinct ALK oncogenic fusion protein involving ALK and echinoderm microtubule-associated protein like 4 (EML4) has been described in the research literature from a non-small cell lung cancer (NSCLC) cell line, with corresponding fusion transcripts present in some cases of lung adenocarcinoma. The short, amino-terminal region of the microtubule-associated protein EML4 is fused to the kinase domain of ALK (6-8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-FGL2凝血酶原酶(纤维介素)抗体
Anti-beta-Amyloid 1-40(CT)β淀粉样肽 1-40（C端）抗体
Anti-KRAS原癌基因K-ras抗体
Anti-P311 protein神经再生相关蛋白抗体
Anti-WDR26心肌缺血预处理正调节蛋白2抗体
Anti-CD56/NCAM1神经细胞粘附分子1抗体
ab102951/Anti-EXOC1 antibody
Anti-PCDH17原钙粘附蛋白17抗体
Anti-HLA G(N-Terminus)人类白细胞抗原G抗体（N端）
ab103078/Anti-FANCA antibody
Anti-MCK10/CD167a/DDR1神经上皮酪氨酸激酶抗体（乳腺癌激酶10）
ab100978/Anti-Chloramphenicol antibody
ab103856/Anti-DHRS13 antibody
ab104310/Anti-beta IV Tubulin antibody
ab100920/Anti-FBP17 antibody
ab103735/Anti-ENTPD8 antibody"
本页产品地址：http://www.geilan.com/sell/show-3245078.html