STING Antibody #3337

"上海博耀生物销售STING Antibody #3337，CST原装品质，价格优惠，订购STING Antibody #3337，详情请咨询销售人员！产品详细参数

"上海博耀生物销售STING Antibody #3337，CST原装品质，价格优惠，订购STING Antibody #3337，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：STING Antibody #3337
货号：3337
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3337S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M	Endogenous	35	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： STING Antibody recognizes endogenous levels of total STING protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu325 of human STING protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

STING (MITA/MYPS/TMEM173) is a recently identified adaptor found to be a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1, 2). It is ubiquitously expressed, resides in the ER, and has five transmembrane regions (1). Detection of cytoplasmic DNA by nucleic acid sensors such as DDX41 or IFI16 leads to their association with STING (3, 4). This causes STING, in a complex with TBK1, to traffic through the Golgi to perinuclear endosomes where TBK1 phosphorylates and activates IRFs and NF-κB, ultimately leading to induction of type I interferon and other genes important for the immune response. In addition, RIG-I, the cytoplasmic receptor for 5’ triphosphorylated viral RNA, was shown to associate with and require STING for induction of type I interferon (1). Finally, STING was recently demonstrated to be a direct sensor of cyclic dinucleotides produced by bacteria (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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