3339 Ras (27H5) Rabbit mAb #3339

"上海博耀生物销售Ras (27H5) Rabbit mAb #3339，CST原装品质，价格优惠，订购Ras (27H5) Rabbit mAb #3339，详情请咨询销售人员

"上海博耀生物销售Ras (27H5) Rabbit mAb #3339，CST原装品质，价格优惠，订购Ras (27H5) Rabbit mAb #3339，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ras (27H5) Rabbit mAb #3339
货号：3339
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3339P	40 ul (4 western blots)	询价
3339S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk Dm Sc	Endogenous	21	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  Dm=D. melanogaster  Sc=S. cerevisiae
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ras (27H5) Rabbit mAb detects endogenous levels of total K-Ras, H-Ras and N-Ras proteins.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human K-Ras.
抗体背景：

The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms (1). Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway (2-4). GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway (5). The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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