3294 IRE1α (14C10) Rabbit mAb #3294

"上海博耀生物销售IRE1α (14C10) Rabbit mAb #3294，CST原装品质，价格优惠，订购IRE1α (14C10) Rabbit mAb #3294，详情请咨询

"上海博耀生物销售IRE1α (14C10) Rabbit mAb #3294，CST原装品质，价格优惠，订购IRE1α (14C10) Rabbit mAb #3294，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：IRE1α (14C10) Rabbit mAb #3294
货号：3294
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： IRE1α
规格：

No.	Size	Price
3294P	40 ul (4 western blots)	询价
3294S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M	Endogenous	130	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： IRE1α (14C10) Rabbit mAb detects endogenous levels of total IRE1α protein.
来源及纯化方法： IRE1α (14C10) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding His963 of human IRE1α.
抗体背景：

The secretory, intra-organellar and transmembrane proteins translocate into the endoplasmic reticulum (ER) after their synthesis. Inside the ER, they are post-translationally modified and properly folded. Disruptions of ER homeostasis leads to the accumulation of unfolded proteins (1). The ER has developed an adaptive mechanism called unfolded protein response (UPR) to counteract compromised protein folding (1). One of the players in UPR, IRE1, was first identified in Saccharomyces cerevisiae as a transmembrane serine/threonine kinase (2-4). This kinase was proposed to be a proximal sensor for UPR that transmits the unfolded protein signal across the ER membrane (3,4). A human homolog of this kinase, IRE1α, was later identified and shown to be ubiquitously expressed in human tissues (5). Upon activation of UPR, IRE1α splices X-box binding protein (XBP1) mRNA by an unconventional mechanism using its endoribonuclease activity (6). This converts XBP1 into a potent transcriptional activator that induces many UPR responsive genes (6). Recently, IRE1α was shown to mediate the rapid degradation of certain mRNAs based on the ER-localization and primary sequences of their encoded proteins, suggesting a novel mechanism in UPR (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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