3266 ROS1 (69D6) Mouse mAb #3266

"上海博耀生物销售ROS1 (69D6) Mouse mAb #3266，CST原装品质，价格优惠，订购ROS1 (69D6) Mouse mAb #3266，详情请咨询销售人员

"上海博耀生物销售ROS1 (69D6) Mouse mAb #3266，CST原装品质，价格优惠，订购ROS1 (69D6) Mouse mAb #3266，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：ROS1 (69D6) Mouse mAb #3266
货号：3266
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
3266S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H	Endogenous	258 kDa	Mouse IgG1

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ros (69D6) Mouse mAb detects endogenous levels of total Ros protein. This antibody does not cross-react with other related proteins.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a GST-Ros fusion protein containing the carboxyl-terminal sequence of human Ros.
抗体背景：

ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus (1). ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in differentiation of epididymal epithelium (2). The first oncogenic fusion of ROS1, FIG-ROS1, was initially identified by research studies in glioblastoma (3), and subsequent studies have found this fusion in cholangiocarcinoma (4), ovarian cancer (5) and non-small cell lung cancer (NSCLC) (6). Investigators have found additional oncogenic ROS1 fusion proteins in NSCLC (at a frequency of ~1.6%), where the ROS1 kinase domain is fused to the amino-terminal region of a number of different proteins, including CD74 and SLC34A2 (6-8). ROS1 fusion proteins activate the SHP-2 phosphatase, PI3K/Akt/mTOR, Erk, and Stat3 pathways (3,4,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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