3234 Phospho-Gab1 (Tyr307) Antibody #3234

"上海博耀生物销售Phospho-Gab1 (Tyr307) Antibody #3234，CST原装品质，价格优惠，订购Phospho-Gab1 (Tyr307) Antibody #3234，

"上海博耀生物销售Phospho-Gab1 (Tyr307) Antibody #3234，CST原装品质，价格优惠，订购Phospho-Gab1 (Tyr307) Antibody #3234，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Gab1 (Tyr307) Antibody #3234
货号：3234
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3234P	40 ul (4 western blots)	询价
3234S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M	Endogenous	115	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Gab1 (Tyr307) Antibody detects endogenous levels of Gab1 only when phosphorylated at tyrosine 307. The antibody cross-reacts with phosphorylated Gab2 and may also cross-react with phosphorylated Gab3. The antibody may cross-react with activated receptor tyrosine kinases (RTKs).
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr307 of human Gab1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold (1-4). Multiple tyrosine phosphorylation sites of Gab1 protein have been identified (5). Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase (6,7). Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ (8). Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2 (6,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab104000/Anti-C9orf78 antibody
Anti-HSP70/HSPA1A热休克蛋白-70抗体
Anti-Fibulin 5衰老关键蛋白抗体
ab103657/Anti-Clathrin light chain antibody
ab103113/Anti-Calpain 10 antibody
ab101840/Anti-AIMP2/p38 antibody
ab103315/Anti-BASP1 antibody
Anti-MAG-a/b髓鞘相关糖蛋白a/b抗体
Anti-PEG10肝癌高表达基因抗体
ab102999/Anti-CES3 antibody
ab10068/Anti-Fibrinogen antibody
Anti-Insulin/Proinsulin胰岛素抗体
Anti-BCHE (NT)丁酰胆碱酯酶抗体(N端)
ab103988/Anti-DCTD antibody
Anti-GLP-2胰高血糖素样肽-2抗体
Anti-CaMK2a/CaMKII钙/钙调素依赖蛋白激酶2α抗体"
本页产品地址：http://www.geilan.com/sell/show-3244964.html