3226 TAB1 (C25E9) Rabbit mAb #3226

"上海博耀生物销售TAB1 (C25E9) Rabbit mAb #3226，CST原装品质，价格优惠，订购TAB1 (C25E9) Rabbit mAb #3226，详情请咨询销售

"上海博耀生物销售TAB1 (C25E9) Rabbit mAb #3226，CST原装品质，价格优惠，订购TAB1 (C25E9) Rabbit mAb #3226，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：TAB1 (C25E9) Rabbit mAb #3226
货号：3226
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3226S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H Mk	Endogenous	60	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： TAB1 (C25E9) Rabbit mAb detects endogenous levels of total TAB1 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro381 of human TAB1.
抗体背景：

TAK1 is a mitogen-activated protein kinase kinase kinase activated by TGF-β and various pro-inflammatory signals (1,2). In vivo, TAK1 activation requires its association with TAK1 binding protein 1 (TAB1), which triggers TAK1 autophosphorylation at Thr184 and Thr187 (3,4). The TAB2 adaptor protein links TAK1 with TRAF6 to mediate TAK1 activation following IL-1 stimulation (5). Once activated, TAK1 phosphorylates the MAPK kinases MKK4 and MKK3/6, which activate JNK and p38 MAPK, respectively. TAK1 and TRAF6 also activate the NF-κB pathway by phosphorylating the NF-κB inducing kinase (NIK) to trigger subsequent activation of IKK (2,6). In addition to TAK1, TAB1 interacts with and activates p38α MAPK (7). Targeted disruption of the TAB1 gene in mice causes a drastic reduction in TAK1 activity and leads to embryonic lethality (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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