3219 TRAIL (C92B9) Rabbit mAb #3219

"上海博耀生物销售Dvl3 Antibody #3218，CST原装品质，价格优惠，订购Dvl3 Antibody #3218，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售Dvl3 Antibody #3218，CST原装品质，价格优惠，订购Dvl3 Antibody #3218，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Dvl3 Antibody #3218
货号：3218
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3218P	40 ul (4 western blots)	询价
3218S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Hm Mk Mi B	Endogenous	88 to 93	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key  Mi=Mink  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Dvl3 Antibody detects endogenous levels of total Dvl3 protein. This antibody does not cross-react with Dvl2.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the carboxy terminus of human Dvl3. The antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK (1,2). There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated (3) and accumulate in the nucleus (4). Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes (5) and mediate endocytosis of the Fzd receptor after Wnt protein stimulation (6). Overexpression of Dvl has been reported in certain cancers (7,8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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