3224 Dvl2 (30D2) Rabbit mAb #3224

"上海博耀生物销售Dvl2 (30D2) Rabbit mAb #3224，CST原装品质，价格优惠，订购Dvl2 (30D2) Rabbit mAb #3224，详情请咨询销售人

"上海博耀生物销售Dvl2 (30D2) Rabbit mAb #3224，CST原装品质，价格优惠，订购Dvl2 (30D2) Rabbit mAb #3224，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Dvl2 (30D2) Rabbit mAb #3224
货号：3224
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3224P	40 ul (4 western blots)	询价
3224S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	90 to 95	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Dvl2 (30D2) Rabbit mAb detects endogenous levels of total Dvl2 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly176 of human Dvl2.
抗体背景：

Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK (1,2). There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated (3) and accumulate in the nucleus (4). Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes (5) and mediate endocytosis of the Fzd receptor after Wnt protein stimulation (6). Overexpression of Dvl has been reported in certain cancers (7,8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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