3233 Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb #3233

"上海博耀生物销售Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb #3233，CST原装品质，价格优惠，订购Phospho-Gab1 (Tyr627) (C32H2

"上海博耀生物销售Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb #3233，CST原装品质，价格优惠，订购Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb #3233，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb #3233
货号：3233
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3233P	40 ul (4 western blots)	询价
3233S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H (M) (R)	Endogenous	110	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb detects endogenous levels of Gab1 only when phosphorylated at Tyr627. The antibody may cross-react with phosphorylated Gab2 or Gab3, or with activated receptor tyrosine kinases (RTKs).
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr627 of human Gab1.
抗体背景：

The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold (1-4). Multiple tyrosine phosphorylation sites of Gab1 protein have been identified (5). Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase (6,7). Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ (8). Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2 (6,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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