3223 Ret (C31B4) Rabbit mAb #3223

"上海博耀生物销售Ret (C31B4) Rabbit mAb #3223，CST原装品质，价格优惠，订购Ret (C31B4) Rabbit mAb #3223，详情请咨询销售人

"上海博耀生物销售Ret (C31B4) Rabbit mAb #3223，CST原装品质，价格优惠，订购Ret (C31B4) Rabbit mAb #3223，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ret (C31B4) Rabbit mAb #3223
货号：3223
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3223S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IF-IC F	H	Endogenous	170, 175	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ret (C31B4) Rabbit mAb detects endogenous levels of total Ret protein. This antibody does not cross-react with other related proteins.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a recombinant human Ret cytoplasmic domain fusion protein.
抗体背景：

The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors (1). Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin, and artemin (2-4). Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung’s disease (1,3). The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr at position 905 dramatically inhibits Ret autophosphorylation activity (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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