3215 AP-2α (C83E10) Rabbit mAb #3215

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"上海博耀生物销售AP-2α (C83E10) Rabbit mAb #3215，CST原装品质，价格优惠，订购AP-2α (C83E10) Rabbit mAb #3215，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：AP-2α (C83E10) Rabbit mAb #3215
货号：3215
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3215S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IF-IC	H M R Mk	Endogenous	48	Rabbit IgG

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： AP-2α (C83E10) Rabbit mAb detects endogenous levels of total AP-2α protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to human AP-2α.
抗体背景：

The sequence-specific transcription factor activator protein 2α (AP-2α) is required for normal growth and morphogenesis during mammalian development (1,2). Decreased or loss of AP-2α expression has been observed in many different types of human cancers including breast cancer (3,4), ovarian cancer (5), melanoma (6) and prostate cancer (7). These findings suggest that AP-2α expression plays a crucial role in tumorigenicity. Studies have also shown that p53 overexpression in human breast carcinoma cells induces the level of AP-2α expression. Furthermore, p53 binds to the cis-element in the AP-2α promoter, suggesting that AP-2α is a target of p53. AP-2α may mediate the effect of p53 to inhibit cell proliferation (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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