3209 Mic-1 (L300) Antibody #3209

"上海博耀生物销售Mic-1 (L300) Antibody #3209，CST原装品质，价格优惠，订购Mic-1 (L300) Antibody #3209，详情请咨询销售人员

"上海博耀生物销售Mic-1 (L300) Antibody #3209，CST原装品质，价格优惠，订购Mic-1 (L300) Antibody #3209，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Mic-1 (L300) Antibody #3209
货号：3209
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3209S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H (Mk)	Endogenous	35, 13	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Mic-1 (L300) Antibody detects endogenous levels of total Mic-1 protein including its active processed form.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human Mic-1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15 (1), PTGF-β (2), PLAB (3), PDF (4), and NAG-1 (5), is a divergent member of the transforming growth factor-β (TGF-β) superfamily (6). Like other family members, Mic-1 is synthesized as an inactive precursor that undergoes proteolytic processing involving removal of an N-terminal hydrophobic signal sequence followed by cleavage at a conserved RXXR site generating an active C-terminal domain that is secreted as a dimeric protein. Mic-1 is highly expressed in the placenta and is also dramatically increased by cellular stress, acute injury, inflammation, and cancer. In the brain, Mic-1 is found in the choroid plexus and is secreted into the cerebrospinal fluid (7). It is also a transcriptional target of the p53 tumor suppressor protein and may serve as a biomarker for p53 activity (8,9). During tumor progression, Mic-1 has various effects on apoptosis, differentiation, angiogenisis, and metastasis, and may also contribute to weight loss during cancer (10,11).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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