3145 Ezrin Antibody #3145

"上海博耀生物销售Ezrin Antibody #3145，CST原装品质，价格优惠，订购Ezrin Antibody #3145，详情请咨询销售人员！产品详细参数

"上海博耀生物销售Ezrin Antibody #3145，CST原装品质，价格优惠，订购Ezrin Antibody #3145，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ezrin Antibody #3145
货号：3145
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3145S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IHC-P IF-IC F	H M R Mk B	Endogenous	81	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ezrin Antibody detects endogenous levels of total ezrin protein. This antibody does not cross-react with ezrin homologues such as radixin and moesin.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human ezrin. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The ezrin, radixin, and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling, and microvilli formation (1). ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers (2). Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin) disrupts the amino- and carboxy-terminal association and may play a key role in regulating ERM protein conformation and function (3,4). Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogene-induced transformation (5). Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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