3132 VASP (9A2) Rabbit mAb #3132

"上海博耀生物销售VASP (9A2) Rabbit mAb #3132，CST原装品质，价格优惠，订购VASP (9A2) Rabbit mAb #3132，详情请咨询销售人员

"上海博耀生物销售VASP (9A2) Rabbit mAb #3132，CST原装品质，价格优惠，订购VASP (9A2) Rabbit mAb #3132，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：VASP (9A2) Rabbit mAb #3132
货号：3132
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3132P	40 ul (4 western blots)	询价
3132S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IF-IC	H M R Hm Mk B	Endogenous	46, 50	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： VASP (9A2) Rabbit mAb detects endogenous levels of total VASP protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human and mouse VASP.
抗体背景：

Vasodilator-stimulated phosphoprotein (VASP) was originally characterized as a substrate of both cGMP- and cAMP-dependent kinases (PKG and PKA, or cGPK and cAPK, respectively) (1). It is now believed that VASP belongs to the Ena/VASP family of adaptor proteins linking the cytoskeletal system to the signal transduction pathways and that it functions in cytoskeletal organization, fibroblast migration, platelet activation and axon guidance (2,3). Three phosphorylation sites, Ser157, Ser239, and Thr278, have been identified. Ser239 is the major PKG phosphorylation site while Ser157 is the major PKA phosphorylation site (4). Evidence suggests that VASP phosphorylation reduces its association with actin and has a negative effect on actin polymerization (5). Phosphorylation at Ser239 of VASP is a useful marker for monitoring PKG activation and signaling (6,7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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