3134 α-Actinin Antibody #3134

"上海博耀生物销售α-Actinin Antibody #3134，CST原装品质，价格优惠，订购α-Actinin Antibody #3134，详情请咨询销售人员！产

"上海博耀生物销售α-Actinin Antibody #3134，CST原装品质，价格优惠，订购α-Actinin Antibody #3134，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：α-Actinin Antibody #3134
货号：3134
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3134S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IF-IC	H M R Hm Mk	Endogenous	100	Rabbit

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： α-Actinin Antibody detects endogenous levels of total α-actinin-1 protein. Based on sequence homology, the antibody may cross-react with α-actinin isoforms 2 and 4.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to carboxy-terminal residues of human α-actinin-1.
抗体背景：

α-Actinin belongs to the spectrin family of cytoskeletal proteins. It was first recognized as an actin cross-linking protein, forming an antiparallel homodimer with an actin binding head at the amino terminus of each monomer. More recently, α-actinin has been shown to interact with a large number of proteins involved in signaling to the cytoskeleton including those involved in cellular adhesion, migration, and immune cell targeting (1). The interaction of α-actinin with intercellular adhesion molecule-5 (ICAM-5) helps to promote neurite outgrowth (2). In osteoblasts, interaction of α-actinin with integrins stabilizes focal adhesions and may protect cells from apoptosis (3). Isoforms 1 and 4 of α-actinin, which are non-muscle isoforms, are present in stress fibers, sites of adhesion and intercellular contacts, filopodia, and lamellipodia. The muscle isoforms 2 and 3 localize to the Z-discs of striated muscle and to dense bodies and plaques in smooth muscle (1).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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